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8 Much like concurrent food consumption causing time-delay in APAP absorption, a patient with chronic liver disease is at risk of prolonged drug serum half-life (by an average of 2.0 to 2.5 hours, and up to more than 4 hours), especially if extended-release APAP formulations are consumed

Several in vitro models such as primary trophoblast cells, placental immortal cell lines, and placental explants have frequently been used [26,27,28]

All human genes associated with these categories were obtained by propagating gene membership in the GO hierarchical tree using the GO.db (v.3.14), AnnotationDbi (v.1.56.2) and org.Hs.eg.db (v.3.14.0) packages in R (date of access: 7 April 2022)

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