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This pro-inflammatory islet environment is termed insulitis ( Figure 2 )

8 Mice with Gpx4 haploinsufficiency in neutrophils developed spontaneous lupus-like disease, while Gpx4 fl/fl LysMCre + mice exhibited mild autoimmunity

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These results indicate that neutrophil ferroptosis is the main cause of neutrophil depletion in lupus, and targeting neutrophil ferroptosis can be an effective therapeutic strategy for treating SLE

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Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase