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Cell culture studies have shown that NNMT inhibition increases intracellular NAD+ levels, enhances sirtuin activity, and shifts adipocyte metabolism toward greater fatty acid oxidation

It is also important to consult with a healthcare provider before starting B12 shots, especially for those on medications that may interfere with B12 absorption or metabolism

In: Bland KI, Sarr MG, Buchler MW, Csendes A, Garden OJ, Wong J, editors

Serum Vitamin B12 levels and methylmalonic acid (MMA) tests help confirm the deficiency

There is also concern about the potential for excessive or rapid weight loss when combining treatments, which may increase the risk of nutritional deficiencies, particularly in protein, vitamins, and minerals

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