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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Krajcovicova-Kudlackova M., Valachovicova M., Mislanova C., Hudecova Z., Sustrova M., Ostatnikova D

Expression of interferon beta (IFN-), IL-1, IL-1, IL-6, IL-10, TNF-, colony-stimulating factor 2 (CSF-2), colony-stimulating factor 3 (CSF-3), chemokines CCL2 (chemokine ligand 2), and CXCL10 (C-X-C motif chemokine ligand 10), transcription factor NF-B, IB, and COX-2 are all decreased in genistein-pretreated LPS-induced RAW264.7 macrophages (103) ( Supplementary Table 1 )

The mechanistic evidence is strong

At the same time, in our previous study on the protective effect of Ebselen on renal ischemia-reperfusion injury, we found that the expression level of GPX3 in renal tissues decreased after renal IRI, and when the level of GPX3 increased after the use of Ebselen, the pathological damage of renal histologic damage was alleviated, and we speculated that GPX3 may play an important role in the oxidative stress response of renal ischemia-reperfusion injury ( FIGURE 3 2.4 GPX4 Glutathione peroxidase 4 (GPX4) is a membrane-associated phospholipid hydroperoxidase and the only enzyme in the GPX family that directly reduces and destroys lipid hydroperoxides, GPX4 is characterized early and characterizes as the lipid peroxidation inhibitory protein PIP, mainly due to its unique ability ( 2 O 2 and small molecule hydroperoxides, it is also capable of reducing complex lipid compounds such as phospholipids, cholesterol and cholesterol lipid hydroperoxides

It has been studied for its remarkable healing properties in various tissues, including the gut

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