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Under low-energy conditions, AMPK phosphorylates specific enzymes and growth control nodes to increase ATP production and decrease ATP consumption (42)

Proteins required for cAMP signaling such as protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC-1) were found to be increased along with restored GLP-1/cAMP levels, indicating cardioprotection [22]

[DOI] [PubMed] [Google Scholar] 49.Veldhuizen EJ, Schneider VA, Agustiandari H, Van Dijk A, Tjeerdsma-van Bokhoven JL, et al

Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities