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Inhibition of hedgehog signaling alters fibroblast composition in pancreatic cancer

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All experiments were carried out in accordance with the European Community Council Directive of 24th November 1986 (86/609/ECC)

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However, in the presence of cystine, the intracellular GSSG levels of the tested strains increased significantly (nearly 45-fold), and the GSH/GSSG ratio decreased from 55140 to 0.10.5 (Figures 4A,B)