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The incidence of renal dysfunction is related to the severity of the acetaminophen ingestion * : Patients with liver involvement but no hepatic failure: ~5% Patients with severe poisoning:10% Patients with acute hepatic failure: ~50% Pathogenesis * Direct toxicity by toxic metabolites of APAP, oxidized by CYP in the kidney

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In the study on the ISO-induced myocardial damage, it was discovered that the cardiac lesions varied with treatment duration and doses and that numerous macrophages were observed in the necrotic areas (Zhang et al

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