A well-designed carrier system can shield B12 from degradation, facilitate its transport through the GI tract, control its release at the appropriate site in small intestine (the ileum), and promote efficient absorption
[125] The ability to absorb vitamin B 12 declines with age, particularly in individuals over 60
Absorption efficiency differences remain the main factor affecting outcome variability, with injection methods producing reliable pharmacokinetic behavior in laboratory settings
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Contamination and unverified purity in compounds sold strictly as research chemicals, since no regulatory body checks their concentration or sterility