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NB (0.97) performed the highest AUCs for the plasma sample

FASN, a key enzyme in lipogenesis, catalyzes the synthesis of long-chain fatty acids, which are then used to synthesize neutral lipids, such as acylglycerols and CEs (37, 38)

Importantly, FIH studies also provide essential information for the design of Phase 2 trials , including decisions related to dosing schedules, administration frequency and safety monitoring strategies

Oxidative Stress and Kidney Damage Oxidative stress is a significant factor in kidney disease progression

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These linkers do not release the drug until the ADC is internalized and the antibody component is degraded within the lysosome, ensuring that the cytotoxic agent is not unleashed at off-target sites