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For example, intracellular Ca 2+ overload induces a transient oxidative stress in the organism and promotes the generation of ROS, which activate injurious signaling through transient receptor potential subtype anchor protein 1 channels (Takano et al., 2007)

183,184 Finally, activation of the ALR/G protein-coupled high-affinity receptor in rats increases TNF- and IL-6 expression via the p38-MAPK pathway, thereby modulating the local immune microenvironment through macrophage activation and enhancing hepatic regeneration after PHx

The Al tolerance in plants may be improved by improvisation of signals from rhizosphere into cellular responses by exogenous application of chemical residues

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