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Sensing the mechano-chemical properties of the extracellular matrix

The mitochondrial membranes are rich in polyunsaturated fatty acids, making them highly susceptible to a specific type of oxidative damage known as lipid peroxidation

In addition, exercise activates the AMPK signaling pathway, accelerating fatty acid -oxidation, effectively reducing hepatic lipid accumulation, and improving blood lipid profiles, as evidenced by increased HDL levels and decreased LDL levels (Bekheit et al., 2025)

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Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism