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it also serves as a critical signaling mechanism within cells by sensing the presence of oxidative stresses and, in turn, turning on other important protective systems in the cell

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Pawley L.C., Hueston C.M., OLeary J.D., Kozareva D.A., Cryan J.F., OLeary O.F., Nolan Y.M

10.1182/blood.2021012070 35 HvidbergV.ManieckiM

The purpose of the modeling was to answer questions posed by experiments or experimentalists and to investigate mechanisms of regulation in one-carbon metabolism

Palacios N, Bhupathiraju SN, Kelly RS, Lee JS, Ordovas JM, Tucker KL

This highlights the need for new approaches [254, 255]