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The use of single agent that is both an antioxidant and anti-inflammatory, and agent such as extracts from medicinal plants, hold the most potential in the re-establishment of redox homeostasis, prevention of excessive inflammation, and the enhancement of a coordinated wound repair process in diabetic patients
Inborn errors of metabolism mainly include diseases such as fatty acid oxidation defects, mitochondrial dysfunctions, organic acidurias, as well as lysosomal and glycogen storage disorders
These drugs are non-selective inhibitors of the COX-2 enzyme, which produces inflammatory mediators by metabolizing arachidonic acid (Bulun 2009)
however, its exact contribution to brain Se transport was not systematically studied and it seems to be rather limited since megalin / mice do not exhibit neurological phenotype associated with Se deficiency (Kurokawa et al., 2014b), typical for Selenop / or Lrp8 / mice
JACC 84 , 16321642 (2024)
24 , 497w504 (2018)
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