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Integrating UGT inhibition data into the rule-of-two model significantly enhances the prediction accuracy for drug-induced liver injury (DILI) (119)

In Trial C4671005 (EPIC-HR), 1,038 subjects received PAXLOVID and 1,053 subjects received placebo

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2:119129 Monsalve M, Olmos Y (2011) The complex biology of FOXO

Nasal spray delivers lower bioavailability than injection, typically 40-60% compared to 80-95% for subcutaneous administration