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Lipid metabolism is another important process that involves SAM-dependent methylation

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Twice-weekly protocols balance convenience with more stable glutathione availability, representing a common middle ground for maintenance therapy

107 Apart from the regulation in transcription level, PPAR modulates PGC-1 in post-translational modification

In a mouse model with I/R injury, the combination of cyclosporine A (CsA) and DFX synergistically inhibits I/R-induced iron overload, lipid peroxidation, and cardiomyocyte ferroptosis, reducing infarct size and improving poor cardiac remodeling after I/R injury