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Findings indicated that rabbits exposed to the combination of AOD 9604 and hyaluronic acid appeared to exhibit the least degeneration in cartilage tissue in these laboratory models

Staresinic M., Japjec M., Vranes H., Prtoric A., Zizek H., Krezic I., Gojkovic S., Smoday I.M., Oroz K., Staresinic E., et al

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For healthy individuals in a research setting using appropriate doses, this temporary increase is a normal physiological response (reflex tachycardia) to vasodilation