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200 nM) to evaluate mitochondrial membrane potential, and MitoSOX (5 M) to detect mitochondrial superoxide levels (all probes sourced from Molecular Probes)

Adv Nutr 10:876887

It is also why elevated IGF-1 raises theoretical concerns about cancer promotion in individuals with pre-existing malignancy or strong genetic risk.8 Any peptide protocol in an adult over 60 must include a pre-treatment cancer screen and should not be initiated in individuals with active or recent cancer history without oncology input

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Intranasal delivery is widely used because it allows the peptide to partially bypass the bloodbrain barrier through the olfactory nerve pathways, helping it reach the central nervous system more efficiently than oral administration