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Lactate Dehydrogenase (LDH) Assay The relative amounts of LDH released into the media (conducted in triplicates for each group) were determined using CytoTox-ONE Homogeneous Membrane Integrity Assay kit Cat.#G7892 (Promega, USA) according to the manufacturers instructions

P values were derived from two-sided Pearsons chi-square tests ( b ), One-way ANOVA ( c,f,h ), two-sided unpaired t-test ( g )

Tyagi A, Yuan B, Ly S, El-Dana F, Kuruvilla V, Zhang Q, Zhou X, deCrombrugghe B, Konopleva M, Andreeff M , Battula VL

Physiological levels of ROS are required for vasoconstriction and thrombus development, which limit local blood flow

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One of the primary reasons B12 is so crucial is that the body cannot produce it on its own