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Because the body does not make B12 on its own, we must get it through food or supplementation

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Sertraline responders also show reductions in KYN/melatonin and 3-HK/melatonin ratios changes absent in non-responders [195] further supporting the notion that a shift in KP metabolite concentrations contributes to antidepressant efficacy

Arias E, Rostron BL, Tejada-Vera B (2010) United States life tables, 2005

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