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Negative Feedback Regulation Importantly, Sermorelin stimulation is subject to physiological regulation through the somatostatin-GHRH axis: when GH and IGF-1 levels rise, this triggers negative feedback at the hypothalamus, stimulating release of somatostatin (also called growth hormone-inhibiting hormone or GHIH) from periventricular hypothalamic neurons

538 Conversely, when HMGB1 is fully reduced, it can facilitate tissue repair through CXCR4, suggesting the significant role of oxidation-reduction modifications in these processes

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Senescent cells were established via DOX-induced senescence

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