Auranofin mediates mitochondrial dysregulation and inflammatory cell death in human retinal pigment epithelial cells: implications of retinal neurodegenerative diseases
consequently, less is known about the settings where there is an overabundance of NADH reducing equivalents, termed reductive stress
Translocates from mitochondria to the nucleus under metabolic stress, where it regulates nuclear gene expression related to mitochondrial biogenesis, antioxidant responses, proteostasis, and metabolic adaptation
Aboushousha R, van der Velden J, Hamilton N, Peng Z, MacPherson M, Erickson C, et al
Some trials have shown that increasing glutathione levels can lead to improvements in how the body handles glucose
Expected m/z for [E-Met+H] + (a), [E + H] + (b), [E-Met+GSH + H] + (c), and [E + GSH + H] + (d) are indicated