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These mutants were also more susceptible than WT to another ITC, sulforaphane

Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice

Glutathione is thought to brighten skin in two linked ways: by inhibiting tyrosinase (the key enzyme in pigment production) and by shifting melanin synthesis from darker eumelanin toward lighter pheomelanin

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The acquired data showed that the addition of PF significantly elevated melanin content and intracellular tyrosinase activity