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DAG-mediated activation of protein kinase C theta (PKC ) leads to phosphorylation of IRS residue S307

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[5] Altered sleep patterns, difficulty concentrating, irritability, overactivity, excitability, mental depression, confusion and impaired judgement have all been reported in patients receiving 15 mg of folic acid daily for 1 month

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cAMP binds PKA, causing the regulatory subunits to dissociate from the catalytically active subunits, resulting in increased activity of the enzyme (60)