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The A1298C variant causes less of a change to the way the enzyme works, with two copies of the variant decreasing enzyme function by around 20%

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Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN (2014) Toxicity, mechanism and health effects of some heavy metals

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Following incubation with shRNA-containing lentiviral particles, or FOXO4-DRI, as indicated, the slices were fixed for 30min in formalin and stored at 80