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Vitamin C is involved in collagen metabolism and integrity, so its use prevents ROS-induced collagen injury to chorioamniotic membranes, reducing PPROM, as shown in different studies [15,86,87,88,94,95]

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To measure the fasting insulin levels, the blood samples were obtained from the orbital venous plexus, and plasma samples were isolated by centrifugation at 12,000 rpm for 10 min at 4 C

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Most of the research has been in animals or labs, not humans, says Paul Knoepfler, a cell and molecular biologist at University of California, Davis