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doi: 10.1038/s41598-019-51298-3

injections with tesaglitazar (2 mg/kg body weight) for 7 days showed lower mitochondrial abundance (67%

Table 1 : Fictitious Example (If a patient has an estriol of 2, an estrone of 2, a 16 a-OHE1 of 2, and an estradiol of 2, then the Total Estrogen Effect (TEE) would be 48 based on their relative binding affinities) **Although 16a-OHE1 is a Phase I metabolite, it is included in the calculation due to its ability to contribute to estrogen dominance

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Could one affect the clearance rate of the other, potentially altering the antibiotic's effective concentration