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10.1016/j.mito.2007.02.011 Mitochondrion

A multi-peptide blend adds a wrinkle: the four components may have different solubilities and stabilities, so a blend is not necessarily as forgiving as a single well-characterized peptide, and there is no standardized, validated reconstitution protocol for KLOW the way there is for approved injectables

& Kyttaris, V

VPA up- regulated levels of BDNF, Bcl-2, and TrkB in the retina post-injury (Zhang et al., 2012)

Much of the purported clinical utility is derived from anecdotal accounts or small, uncontrolled series, rather than from robust randomized trials

Finally, dissolved zinc ion contributes to ferroptosis (Zhang C