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BDNF binding to TrkB evokes receptor dimerization and initial phosphorylation of tyrosine residues within the autoregulatory loop of the kinase domain (human TrkB Tyr 706/707 ) followed by autophosphorylation of cytoplasmic conserved tyrosine residues (human TrkB Tyr 515 , Tyr 816 ) 2

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With this information, and after a thorough review of your medical history, Dr