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These include the formation and permeability of the BBB, angiogenesis, CBF, the clearance of toxic cellular metabolites, vascular remodeling, and tone, all of which are essential for the normal functioning of the CNS [39]

IGF-1 is also used in the treatment of age-related health issues, where it can help regenerate tissues and combat the effects of aging

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However, because retatrutide has the additional glucagon receptor component, starting at a lower-than-expected dose and titrating up remains the safest approach