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In addition to this intrinsic diversity, neuronal cues play a critical role in initiating and shaping myelination patterns

The other main functional class of enzymes involved in steroidogenesis are the HSD enzymes which are dependent on NAD(P)H and NAD(P) + co-factors

The mechanisms likely involve immune modulation (microglia in ALS can adopt a neurodegenerative phenotype that might be restrained by microbial signals) and metabolic support (providing nutrients like nicotinamide or SCFAs to neurons and glia) [214, 218]

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