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This research was supported by the Basic Science Research Program through the NRF of Korea funded by the Ministry of Education (2017R1A6A1A03015876)
Phytomedicine 120:155066
Blood Clots Protect Against Damage and Infection Aside from their pro-regenerative properties, blood clots serve the extra function of trapping cellular debris and pathogens from spreading in the circulation, which helps to resolve infection and keep inflammation localized
Nerve growth factor (NGF), released by osteoblasts, endothelial cells, and infiltrating immune cells, plays a key role in promoting this ectopic innervation, establishing a direct link between structural bone changes and pain signaling ( via its receptor DCC, has been shown to drive the sprouting of calcitonin gene-related peptide (CGRP)+ nociceptive fibers in the subchondral bone, thereby contributing directly to pain hypersensitivity associated with OA (Zhu et al., 2019)
Western blotting and Biacore analysis confirmed that L2-Cmu binds to and inhibits IGF-1R activation by IGF-1 (Ki = 3.3 nM) and IGF-2 (Ki = 3.3 nM) (Fig
H., Aalbers, M
