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Irons propensity to catalyze free radical generation through the Fenton reaction has long been implicated in both tumor initiation and the delicate balance of ferroptosis, a form of regulated cell death that chemotherapies often seek to trigger

Girndt, C

Consequently, tumor cells catalyze the synthesis of glutamate and ammonia into endogenous Gln by upregulating the expression of GS to sustain their growth and metastasis

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Alsughayyir J, Alshaiddi W, Alsubki R, Alshammary A, Basudan AM, Alfhili MA

The conclusion was further validated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and H&E staining (Fig