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In an experimental model of abdominal aortic aneurysm, topiramate markedly downregulated pro-inflammatory M1 macrophage activity, reduced the expression of TNF-, IL-1, and matrix metalloproteinase-9, and promoted a phenotypic shift of macrophages from M1 to M2, thereby mitigating pro-inflammatory activity and enhancing tissue repair processes ( These studies collectively suggest that topiramate exerts significant neuroprotective effects across various pathological models through its potent anti-inflammatory properties

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Inhal Toxicol 2013;25:257271

Research teams must keep detailed records of experimental procedures and compound usage

But, if the company describes its product as an immunity booster, the agencys authority is less clear

Because our diets rarely contain perfectly balanced, nutritious meals, many people turn to oral supplements