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Many senolytic drugs are already approved for human use and many cells expressing senescence have been identified in other types of chronic kidney disease, however these studies did not include patients with lupus

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The hCMEC/D3 cell line expresses several purinergic receptors and also CD73 which converts AMP to adenosine (Mills et al., 2011)

A Pre-Sub is a formal written request for feedback from FDA prior to your pre-market submission that you can use to request information on a variety of topics related to your submission