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Brain and Central Nervous System: Vitamin B12 is stored in small amounts in the brain and central nervous system, reflecting its importance in maintaining neurological health

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Deficiencies in B12 or defects in methionine synthase will result in 5-methyl-THF trapping with the result being the development of megaloblastic anemia due to the block in nucleotide production and the inability of bone marrow erythroblasts to proceed through S-phase of the cell cycle