Also diarrhoea, peripheral vascular thrombosis, transitory exanthema, or urticaria
Clean, simple, hard to get wrong
Investigational applications may include studies involving adipocyte differentiation, lipid metabolism, mitochondrial function, energy balance regulation, and controlled biochemical analysis of cellular metabolic responses under standardized experimental conditions
Scientific References (External Links) Nature Chemical Biology: Small molecule inhibitors of nicotinamide N-methyltransferase View Study Biochemical Pharmacology: Nicotinamide N-methyltransferase: A promising target for treating metabolic disorders View Study FASEB Journal: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity in mice View Study Journal of Biological Chemistry: Inhibition of nicotinamide N-methyltransferase in vivo regulates cellular energy metabolism View Study
NNMT depletes the NAD+ precursor pool by methylating nicotinamide the same nicotinamide that the salvage pathway would otherwise convert back into NAD+ via the enzyme NAMPT
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