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Replicating the results of an animal study in large-scale human trials that then lead to regulatory approval has a success rate of around five to 10 per cent, based on several analyses

doi: 10.4158/EP161208.GL 39 CostanteGFilettiS

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Biocompatibility and toxicity concerns Unlike traditional drugs, emerging nanomaterials can exhibit unpredictable reactions within the human body, posing challenges related to biocompatibility and toxicity [229, 230]