GlaxoSmithKline (GSK), Leeds (Yorkshire Centre for Eating Disorders): We acknowledge the support of the Medical Research Council and GlaxoSmithKline for providing financial support of this project
Although increases in bilirubin (likely a mixture of conjugated and unconjugated) are seen in dogs with hepatic failure (Toulza et al 2006) (likely due to a combination of reasons, such as inflammatory cytokine-mediated alteration in transporters, toxicity from accumulated bile acids, alterations in intrahepatic blood flow from fibrosis, hepatocyte swelling resulting in cholestasis), the high bilirubin is not specific for failure and can be seen in various diseases that are not associated with liver failure, e.g
Differences in the catalytic efficiencies of allelic variants of glutathione trans-ferase p1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons
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doi: 10.1038/s41419-022-05384-6 83 OuYWangSJLiDChuBGuW
Proceedings of the Royal Society of London
