n acetyl cysteine precursor of glutathione NAC N-Acetyl-L-Cysteine 120 Tabs N Acetyl Cysteine, Glutathione, &

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Furthermore, our study reveals that metformin can alleviate ECM degradation and inflammation in chondrocytes exposed to H 2 O 2 by reducing oxidative stress-induced damages Additionally, our results establish that metformin exerts its antioxidant effects mainly through the Nrf2 signaling pathway, ultimately slowing OA progression (Fig

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Schneider-Helmert et al

GPX1-4 and GPX6 use selenocysteine as the active center to catalyze the reduction of H 2 O 2 or organic hydroperoxides to water or corresponding alcohols, thereby reducing their toxicity and maintaining redox balance

Glutathione, in contrast, delivers more immediate effects by reducing oxidative stress and supporting detoxification