Conversely, while broad-spectrum PHD inhibitors (e.g., Roxadustat [489]) promote erythropoiesis to treat anemia, their potential pro-oxidant side effects also require careful evaluation, reflecting the dual nature of intervention strategies
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GPX4 (glutathione peroxidase 4) and Quercetin GPX4 is highly expressed in tubular epithelial cells and its level is a predictor for renal outcomes, ferroptosis (antioxidant role in lipid peroxidation), and patients with diabetic kidney disease (DKD) are associated with (Wang, Chang, Zhao, & Chen, 2022) where increased urinary protein, serum creatinine, estimated glomerular filtration rate, and the percentage of sclerosed glomeruli in renal specimens
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