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450 However, in the phase 3 IMpassion131, the combination of atezolizumab with paclitaxel did not improve PFS or OS versus paclitaxel alone in patients with locally advanced TNBC, 451 making the role of atezolizumab in advanced disease controversial and needed to be further confirmed

By comparing the metabolic pathway activities for the gdh3 / gdh3 mutant grown on arginine medium as opposed to on proline medium with the wild-type strain under those growth conditions, there was a greater global metabolic reprogramming for the wild-type cells when grown on arginine compared to growth on proline (Fig

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The GHK-Cu group showed significantly greater total protein and collagen synthesis demonstrating that the peptide's effects on extracellular matrix accumulation extend to systemic injection, not just topical application

Erastin, a ferroptosis inducer, binds to VDAC2 and VDAC3 on the outer mitochondrial membrane, inducing mitochondrial dysfunction and oxidant release, ultimately triggering ferroptosis in tumor cells

10.1242/dev.01209 Development 68 HamanoueM.TakemotoN.MatsumotoK.NakamuraT.NakajimaK.KohsakaS