The carnitines work in different but related ways
We established an FP competition assay to biochemically validate displacement of the TIN2 peptide by the compounds and further showed that compound 40 , identified as one of the most potent analogues amongst the compounds tested, evicted full-length TRF1 from the shelterin complex by disrupting the TRF1 TRFH :TIN2 TBM interaction
Beyer W, Imlay J, Fridovich I
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Huang JX, Li FY, Xiao W, Song ZX, Qian RY, Chen P et al