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The Timeline That Makes You Think The temporal correlation between widespread acetaminophen use and neurodevelopmental disorder prevalence is striking: Acetaminophen adoption : 1955: Tylenol introduced in the United States 1960s-1970s: First use in pregnancy 1980s: Widely recommended as first-line agent Late 1980s-1990s: Increased use for post-vaccination symptom management 2000s-present: 62-65% of pregnant women use acetaminophen