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This limits direct translation to subcutaneous research protocols, because the delivery route and tissue environment differ substantially [7][8]

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Int J Mol Sci 21:1314 Sumiyoshi K, Nakao A, Setoguchi Y, Tsuboi R, Okumura K, Ogawa H (2003) TGF-/Smad signaling inhibits IFN- and TNF--induced TARC (CCL17) production in HaCaT cells