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Importantly, Hinton and colleagues showed that human IgG2 variants harboring Fc fragments with amino acid substitutions that increase their binding affinity towards human FcRn at specifically pH 6.0, but not pH 7.4, had prolonged plasma half-lives in non-human primates (NHPs) [104]

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Lu X, Zhang H, Zhang N, Dong C, Ji H, Yu J, Ban Z, Yan R, Zhang T, Chen C, Jiang Y (2023) Effects of ozone treatment on gene profiling involved in ASA-GSH cycle in postharvest cantaloupe

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Pelissero C, Lenczowski M, Chinzi D, Davail-Cuisset B, Sumpter J, Fostier A