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We demonstrated that GSB-106 acted as a partial TrkB receptor agonist and transactivation mechanisms also could contribute to pro-survival properties of the compound

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HGF, upon binding to its receptor, encoded by the proto-oncogene MET (Naldini et al., 1991), elicits relevant biological activities, including cell motility, division, survival, and differentiation (Trusolino et al., 2010)

Modulates Neuroinflammation Chronic inflammation worsens neurodegeneration