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Some of them are as follows: Small intestine bacterial overgrowth (SIBO): The harmful bacteria use the available B12 before it has been absorbed by the small intestine, thereby leading to a deficiency

74 However, because these results were never formally published in peer-reviewed journals, they have to be taken with caution

We're dealing with more complex conditions

Convenience: Daily supplementation is easy to integrate into a routine, making oral options better suited for long-term use

Obese patients with higher BMIs are at higher risk for having vitamin B12 deficiency and weight loss may potentially worsen the B12 deficiency