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However, neurotrophins have had little success in clinical trials directed at neurodegenerative diseases due to their poor pharmokinetic profile and large molecular weight that significantly impedes penetration of the BBB [61,62]

Neuroprotective effects of palmatine via the enhancement of antioxidant defense and small heat shock protein expression in A-transgenic Caenorhabditis elegans

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The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

Together, this combination is widely utilized in preclinical studies examining growth hormone physiology, tissue regeneration, metabolic shifts, and anti-inflammatory cellular responses

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