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Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

Interest in experimental peptides has boomed in recent years

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Then, the researchers administered exendin-4 via intrathecal injection to the experimental rats and observed a reduction in pain sensitivity, alleviation of neural inflammation, and suppression of inflammatory factors such as IL-1, TNF-, and iNOS

Plant Biol (Stuttg) 11:119130

The first Complete Response Letter, in which the regulator cited manufacturing issues, came in 2017, and the FDA issued a second CRL in March 2022, flagging signals of AKI