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doi: 10.1186/s12951-022-01424-7 98 Jing-JingWMichelle Kwan-YeeSYu-XinJThomas Ho-YinLDavid WaiCHuo-GangWet al

Combination of Y27632 and CHIR99021, or netarsudil and LY2090314 improved liver repopulation in vivo by promoting the dediffereantiation and redifferentiation of hepatocytes

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333 Similarly, mice and rats exhibit an NAD + decline during aging in a variety of tissues, such as muscle, adipose tissue, brain, skin, liver and pancreas

Important limitations of this study are that it was conducted only in a Japanese population, with a short follow-up time of 2 years and in a group of patients with very little progression of renal disease, since the drop of eGFR in the placebo group was less than 1 ml/min/year